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sar7334 hydrochloride (MedChemExpress)

Name: sar7334 hydrochloride
Brand: MedChemExpress
Rating: 93 (22 reviews)

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MedChemExpress sar7334 hydrochloride

Data are presented as the mean ± SD changes over time in blood pressure, tension, RSNA, blood flow and vascular conductance induced by static contraction. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which <t>SAR7334</t> (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade.

Sar7334 Hydrochloride, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 22 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 22 article reviews

sar7334 hydrochloride - by Bioz Stars, 2026-02

93/100 stars

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1) Product Images from "GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition"

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

Journal: The Journal of Physiology

doi: 10.1113/JP289092

Figure Legend Snippet: Data are presented as the mean ± SD changes over time in blood pressure, tension, RSNA, blood flow and vascular conductance induced by static contraction. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade.

Techniques Used: Injection, Activity Assay

Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the integrated changes evoked by static contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panel represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panel represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; TTi, tension time index calculated as the integrated tension response to contraction; RSNAi, integrated renal sympathetic nerve activity. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 between the corresponding data points.

Figure Legend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the integrated changes evoked by static contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panel represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panel represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; TTi, tension time index calculated as the integrated tension response to contraction; RSNAi, integrated renal sympathetic nerve activity. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 between the corresponding data points.

Techniques Used: Injection, Activity Assay

Data are presented as the mean ± SD changes over time in blood pressure, tension and RSNA induced by passive stretch. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of stretch. Stretches were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade. # P < 0.05 between the first and second blockade.

Figure Legend Snippet: Data are presented as the mean ± SD changes over time in blood pressure, tension and RSNA induced by passive stretch. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of stretch. Stretches were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade. # P < 0.05 between the first and second blockade.

Techniques Used: Injection, Activity Assay

Figure Legend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the integrated changes evoked by passive stretch. Stretches were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panel represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panel represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; TTi, tension time index calculated as the integrated tension response to stretch; RSNAi, integrated renal sympathetic nerve activity. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 between the corresponding data points.

Techniques Used: Injection, Activity Assay

Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the percentage changes from baseline in the integrated blood pressure evoked by static contraction and passive stretch. Stretches and contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figure in the left panel represents the effects of SAR7334 (51 ± 8 µ m in 100 µl) alone and the effects of SAR7334 when injected after GsMTx‐4 (51 ± 8 µ m in 100 µl). Figure in the right panel represents the effects of GsMTx‐4 (51 ± 8 µ m in 100 µl) alone and the effects of GsMTx‐4 when injected after SAR7334 (51 ± 8 µ m in 100 µl). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; ∗ P < 0.05 between the corresponding data points.

Figure Legend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the percentage changes from baseline in the integrated blood pressure evoked by static contraction and passive stretch. Stretches and contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figure in the left panel represents the effects of SAR7334 (51 ± 8 µ m in 100 µl) alone and the effects of SAR7334 when injected after GsMTx‐4 (51 ± 8 µ m in 100 µl). Figure in the right panel represents the effects of GsMTx‐4 (51 ± 8 µ m in 100 µl) alone and the effects of GsMTx‐4 when injected after SAR7334 (51 ± 8 µ m in 100 µl). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; ∗ P < 0.05 between the corresponding data points.

Techniques Used: Injection

Data are presented as individual (open dots) and group means (open bars) for the peak inward current evoked by membrane stretch. Membrane stretch was evoked by exposing the cells to hypoosmotic solution (Hypo‐Osm). A more negative value indicates higher inward current. Two concentrations of SAR7334 were used, 1 µ m and 4 µ m , which corresponded to the calculated concentration of drugs reached in the interstium of myocytes following intra‐arterial injections.

Figure Legend Snippet: Data are presented as individual (open dots) and group means (open bars) for the peak inward current evoked by membrane stretch. Membrane stretch was evoked by exposing the cells to hypoosmotic solution (Hypo‐Osm). A more negative value indicates higher inward current. Two concentrations of SAR7334 were used, 1 µ m and 4 µ m , which corresponded to the calculated concentration of drugs reached in the interstium of myocytes following intra‐arterial injections.

Techniques Used: Membrane, Concentration Assay

Image Search Results

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as the mean ± SD changes over time in blood pressure, tension, RSNA, blood flow and vascular conductance induced by static contraction. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Injection, Activity Assay

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the integrated changes evoked by static contraction. Contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panel represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panel represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; TTi, tension time index calculated as the integrated tension response to contraction; RSNAi, integrated renal sympathetic nerve activity. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 between the corresponding data points.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Injection, Activity Assay

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as the mean ± SD changes over time in blood pressure, tension and RSNA induced by passive stretch. The averaged time course includes 2 s of baseline, 30 s of contraction and 2 s after the end of stretch. Stretches were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panels represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panels represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: MAP, mean arterial pressure; RSNA, renal sympathetic nerve activity. † P < 0.05 between pre‐blockade and first blockade. ‡ P < 0.05 between pre‐blockade and second blockade. # P < 0.05 between the first and second blockade.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Injection, Activity Assay

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the integrated changes evoked by passive stretch. Stretches were evoked before, 10 min after the first injection, and 10 min after the second injection. Figures in the left panel represent the experiments during which SAR7334 (51 ± 8 µ m in 100 µl) was injected first and GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected second ( n = 8). Figures in the right panel represent the experiments during which GsMTx‐4 (51 ± 8 µ m in 100 µl) was injected first and SAR7334 (51 ± 8 µ m in 100 µl) was injected second ( n = 9). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; TTi, tension time index calculated as the integrated tension response to stretch; RSNAi, integrated renal sympathetic nerve activity. ∗ P < 0.05, ∗∗ P < 0.01, and ∗∗∗ P < 0.001 between the corresponding data points.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Injection, Activity Assay

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as individual (males as open circles and females as closed circles) and group means (open bars) for the percentage changes from baseline in the integrated blood pressure evoked by static contraction and passive stretch. Stretches and contractions were evoked before, 10 min after the first injection, and 10 min after the second injection. Figure in the left panel represents the effects of SAR7334 (51 ± 8 µ m in 100 µl) alone and the effects of SAR7334 when injected after GsMTx‐4 (51 ± 8 µ m in 100 µl). Figure in the right panel represents the effects of GsMTx‐4 (51 ± 8 µ m in 100 µl) alone and the effects of GsMTx‐4 when injected after SAR7334 (51 ± 8 µ m in 100 µl). Abbreviations: BPi, blood pressure index calculated as the integrated blood pressure response to contraction; ∗ P < 0.05 between the corresponding data points.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Injection

Journal: The Journal of Physiology

Article Title: GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition

doi: 10.1113/JP289092

Figure Lengend Snippet: Data are presented as individual (open dots) and group means (open bars) for the peak inward current evoked by membrane stretch. Membrane stretch was evoked by exposing the cells to hypoosmotic solution (Hypo‐Osm). A more negative value indicates higher inward current. Two concentrations of SAR7334 were used, 1 µ m and 4 µ m , which corresponded to the calculated concentration of drugs reached in the interstium of myocytes following intra‐arterial injections.

Article Snippet: GsMTx‐4 (1 mg; MedChemExpress) and SAR7334 hydrochloride (5 mg; MedChemExpress) were dissolved in 0.9% saline.

Techniques: Membrane, Concentration Assay

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1) Product Images from "GsMTx‐4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition"

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